Cardiovascular disease - a leading cause of morbidity and mortality among adults - is strongly influenced by platelet function through acute thrombotic and atherogenic mechanisms.
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Extracellular vesicles are small extracellular membrane-enclosed vesicles with a lipid bilayer membrane containing different lipids, metabolites, proteins, RNAs and DNAs. Although discovered as early as 1967 and considered to be cell debris they were later recognized as bioactive mediators in cell-to -cell communication and critical players in both physiological and pathological conditions in the 1990s.
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Circular RNA or CircRNA is a type of single stranded RNA over 200 nucleotides long which has a covalent closed loop structure with neither 5′ to 3′ polarity nor polyadenosine (A) tail. These RNAs are widely distributed in mammals, and play an important role in regulating gene expression and various cellular processes.
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