Sepsis is a recognized global health problem.
It affects over 30 million people worldwide annually and is the largest killer of children → 5 million each year.
As already mentioned in Focus on Clusterin! - part one, clusterin is able to form complexes with immunoglobulins, components, paraoxonase, leptin, lipids, heparin, bacteria, complement and others. It can also bind to beta amyloid and inhibit formation of its fibrils.
Clusterin has been connected to a plethora of functions such as phagocyte recruitment, reduced aggregation of serum proteins, prevention of complement attack, apoptosis inhibition, membrane remodeling, lipid transport, hormone transport, matrix metalloproteinase inhibition and reduction of oxidative stress.
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