Cardiovascular disease - a leading cause of morbidity and mortality among adults - is strongly influenced by platelet function through acute thrombotic and atherogenic mechanisms.
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Extracellular vesicles are small extracellular membrane-enclosed vesicles with a lipid bilayer membrane containing different lipids, metabolites, proteins, RNAs and DNAs. Although discovered as early as 1967 and considered to be cell debris they were later recognized as bioactive mediators in cell-to -cell communication and critical players in both physiological and pathological conditions in the 1990s.
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Univentricular heart (UVH) disease is a complex congenital cardiac disorder which accounts for 7,7% of all congenital heart defects. UVH is characterized by only one functional ventricular chamber of right or left ventricular morphology. Infants with this kind of heart defect have to early undergo several palliative procedures resulting in the complete Fontan procedure – redirection of the blood from the lower body to the lungs.
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