The epidermis protects the human body from exogenous stressors and helps to maintain internal fluid and electrolyte homeostasis.
Atopic dermatitis is a chronic cutaneous inflammatory disorder, characterized by intense itching, dry skin, and periodic flares of eczema. A disrupted skin barrier allows entry of allergens and lead to systemic allergic responses, such as increased IgE. Skin in patients with AD always presents microscopic injuries even in remission. These micro-cracks allow the entry of pathogens, allergens, and irritants that contribute to inflammation and infection.
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