Acute coronary syndromes (ACS) are major causes of morbidity and mortality. Despite optimal medical treatment and revascularisation there remains a significant risk of subsequent cardiovascular events.
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Excellent biomarker for long term therapy.
Biomarker of cardiovascular risk and atherosclerotic process.
It is well known that high levels of low-density lipoprotein (LDL) cholesterol in the blood stream may increase the risk of cardiovascular events, myocardial infarction, stroke or other heart disease.
Researcher James Wilson and colleagues at University of Pennsylvania wanted to target PCSK9, a gene whose protein hinders the removal of harmful LDL cholesterol from the blood.
However, reducing levels of a problem protein made in the liver requires editing a large fraction of the organ’s cells.
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