Paraoxonase 1 (Arylesterase 1, PON 1, Aromatic Esterase 1, A-Esterase 1, K-45, Serum Aryldialkylphosphatase 1)

PON 1 Hydrolyzes organophosphate substrates and lactones, and a number of aromatic carboxylic acid esters. It is found in plasma associated with HDL. It mediates an enzymatic protection of lipoproteins against oxidative modification and thus against atheroma formation. Genetic variation in PON1 is associated with susceptibility to microvascular complications in diabetic patients.

• References to Paraoxonase 1 (Arylesterase 1, PON 1, Aromatic Esterase 1, A-Esterase 1, K-45, Serum Aryldialkylphosphatase 1)