Thrombomodulin (CD141) is a 557 amino acid a glycosylated transmembrane protein and is a thrombin receptor located on endothelial cell surface. This surface glycoprotein forms a complex with thrombin that activates protein C, which, in turn, degrades clotting factors V and VIII. Thus, thrombomodulin converts thrombin into a physiologic anticoagulant. Thrombomodulin is also found in the circulatory and urinary systems.
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