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Sincalide

  • Regulatory status:RUO
  • Type:Synthetic protein
  • Source:Synthetic protein
  • Other names:CCK8
  • Species:Human
Cat. No. Size Price


Discount RP1782740001 1 mg $133,38
Discount RP1782740005 5 mg $192,32
Discount RP1782740025 25 mg $537,24
PubMed Product Details
Technical Data

Type

Synthetic protein

Description

Sincalide, a synthetic protein, also called CCK-8 has a molecular formula of C49H62N10O16S3 having an Mw of 1143.29 Dalton.

Amino Acid Sequence

H-Asp-Tyr(SO3H)-Met-Gly-Trp-Met-Asp-Phe-NH2

Source

Synthetic protein

Purity

Greater than 99.0% as determined by RP-HPLC.

Formulation

Sincalide was lyophilized from a concentrated (1 mg/ml) solution with no additives.

Reconstitution

It is recommended to reconstitute the lyophilized Sincalide in sterile 18MΩ-cm H2O at a concentration of 0.5mg/ml, which can then be further diluted to other aqueous solutions.

Shipping

At ambient temperature. Upon receipt, store the product at the temperature recommended below.

Storage/Expiration

Store the lyophilized protein at -80 °C. Lyophilized protein remains stable until the expiry date when stored at –80 °C. Aliquot reconstituted protein to avoid repeated Lyophilized Sincalide although stable at room temperature for 3 weeks, should be stored below -18°C. Upon reconstitution CCK-8 should be stored at 4°C between 2-7 days and for future use below -18°C. Avoid freezing/thawing cycles and store at -80 °C for long term storage. Reconstituted protein can be stored at 4 °C for a week.

Quality Control Test

Greater than 99.0% as determined by RP-HPLC.

Physical Appearance

Sterile filtered white lyophilized (freeze-dried) powder.

Note

This product is intended for research use only.

Summary

Summary

Sincalide also called CCK-8 has a molecular formula of C49H62N10O16S3 Sincalide corresponds to the C-terminal octapeptide of cholecystokinin (CCK) which acts on receptors within the gallbladder wall causing it to contract. Cholecystokinin (CCK) is a hormone originally isolated from porcine intestinal mucosa and described as a linear 33-amino acid peptide containing a sulfated tyrosine, which is essential for its biological activity. It has been found in mammals in both the digestive tract and the central nervous system. Among its multiple biological functions, this hormone stimulates pancreatic exocrine secretion, gallbladder contraction, and intestine motility and may also act as a neurotransmitter/neuromodulator in the central nervous system.

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