Type
Sandwich ELISA, HRP-labelled antibody
Description
The Serum Pre-Clinical CartiLaps® (CTX-II) ELISA detects degradation products of C-terminal telopeptides of type II collagen (CTX-II) in animal serum. The test is intended for research use only, not for use in diagnostic procedures.
Scientific Description:
Disruption of the structural integrity of cartilage is the major histological finding in osteoarthritis and rheumatoid arthritis. Type II collagen is the major organic constituent of cartilage and fragments of type II collagen (CTX-II) are being released into circulation and subsequently secreted into urine following degradation of cartilage. In non-human serum, the CTX-II fragments can be quantified by Serum Pre-Clinical CartiLaps®(CTX-II) ELISA. The Serum Pre-Clinical CartiLaps® (CTX-II) ELISA has been reported to be useful for rat, mice, rabbit, dog, guinea pig and cynomolgus monkey and horse specimens.
Applications
Serum, Plasma, Cartilage Explant Culture Supernatant and Synovial Fluid
Sample Requirements
25 µL/well
Storage/Expiration
Store the complete kit at 2–8°C. Under these conditions, the kit is stable until the expiration date (see label on the box).
Calibration Range
0-300 pg/mL
Limit of Detection
3.7 pg/mL