Type
Recombinant protein
Description
The E.Coli derived recombinant protein contains contains the SARS-CoV-2 spike (S), membrane (M), and envelope (E) immunodominant regions, fused to His tag at C-terminal.
Source
E. coli
Purity
Greater than 90.0% as determined by Analysis by SDS-PAGE.
Formulation
SARS-CoV-2 Spike Envelope-Mosaic Protein 1mg/ml solution is supplied in 1x PBS.
Applications
COVID-19
Storage/Expiration
Shipped on ice packs. Store at -20⁰C upon arrival.
Physical Appearance
Sterile filtered clear solution.
Note
BioVendor's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Research topic
Immune Response, Infection and Inflammation, COVID-19
Summary
Coronaviruses (CoVs), within the order Nidovirales, are enveloped, single-strand, positive-sense RNA viruses with a large genome of approximately 30 kbp in length. A human infecting coronavirus (viral pneumonia) initially known as 2019 novel coronavirus (2019-nCoV) was found in the fish market at the city of Wuhan, Hubei province of China in December 2019. The virus is now named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
SARS-CoV-2 shares an 87% identity to the 2 bat-derived severe acute respiratory syndrome 2018 SARS-CoV-2 located in Zhoushan of eastern China. SARS-CoV-2 has an analogous receptor-BD-structure to that of 2018 SARS-CoV, even though there is a.a. diversity so thus the SARS-CoV-2 might bind to ACE2 receptor protein (angiotensin-converting enzyme 2) in humans.
While bats are possibly the host of SARS-CoV-2, researchers suspect that animal from the ocean sold at the seafood market was an intermediate host. RSCU analysis proposes that the SARS-CoV-2 is a recombinant within the viral spike glycoprotein between the bat coronavirus and an unknown coronavirus.
Coronaviruses contain at least four structural proteins: Spike (S) protein, envelope (E) protein, membrane (M) protein, and nucleocapsid (N) protein.
