Kallikreins(KLKs) belong to the serine protease family of proteolytic enzymes. Neurosin(KLK6), one of these, is atrypsin-like protease dominantly expressed in the human brain but also in a variety of other tissues. As measured by a sensitive quantitative assay in serum and cerebrospinal fluid(CSF), it may have value as a biomarker for diagnosis and monitoring of Alzheimer's disease(AD). It seems to be down regulated in serum and tissues of AD patients and may be involved in amyloid metabolism.
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