Cat # changed from 637-02679 to 633-02671
Type
Direct ELISA, HRP-labelled antibody
Applications
Serum, Plasma-EDTA, Plasma-Citrate
Sample Requirements
1 µl/well
Shipping
At ambient temperature. Upon receipt, store the product at the temperature recommended below.
Storage/Expiration
Store the complete kit at 2–8°C. Under these conditions, the kit is stable until the expiration date (see label on the box).
Calibration Curve
Calibration Range
15.6–1 000 mU/ml
Limit of Detection
0.78 mU/ml
Research topic
Animal studies
Summary
Rheumatoid factors are autoantibodies against Fc region of of IgG and is found in 70-80% of patients suffering from chronic rheumatoid arthritis, and are considered to be closely related to its pathological syndrome. Experimental animal models with spontaneous autoimmune diseases similar to those in humans, and animals with artificially-induced inflammation have been used to elucidate the mechanism of autoimmune diseases and to search for potential new remedies. A representative model animal of spontaneous autoimmune diseases is MRL/lpr mouse. As MRL/lpr shows high incidence of lymph node tumor, nephritis, angitis, and arthritis, this animal strain is useful for studies of the mechanism of human autoimmune diseases including rheumatoid arthritis.
Autoantibodies found in MRL/lpr serum are IgG type rheumatoid factor, IgM type rheumatoid factor, anti-ssDNA antibodies, anti-dsDNA antibodies, and anti-Sm antibody, etc. This kit enables quantification and comparison of IgG type rheumatoid factor with a calibration curve using standard antibody preparation.
Instructions for Use (RUO)
Instructions for Use (RUO)
Safety Information (RUO)
MSDS (RUO)
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