| Cat. No. | Size |
Price |
|
|---|---|---|---|
| RHK374-02R | 2x96 wells (1 kit) |
Sandwich ELISA, Biotin-labelled antibody
Plasma
10 µl/well
Store the complete kit at 2–8°C. Under these conditions, the kit is stable until the expiration date (see label on the box).
0.39-25 ng/ml
0.39 ng/ml
The total assay time is 3.5 hours
The kit measures sCD59 in human Plasma
Assay format is 96 wells
Components of the kit are provided ready to use or concentrated
Cardiovascular disease, Cell surface proteins (sCD)
CD59 is a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. Complement activation ultimately leads to formation of the cytotoxic, poreforming membrane attack complex (MAC), the main effector of complement mediated tissue damage. Insertion of the MAC into cell membranes induces the release of cytokines and growth factors that promote inflammation, thrombosis, and cell proliferation. CD59 is a complement regulatory protein ubiquitously expressed on mammalian cell surfaces and it specifically inhibits MAC formation and thereby protects “self” cells from complement-mediated damage. The protein also plays a role in signal transduction pathways in the activation of T cells. Mutations in the CD59 gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction. CD59 was demonstrated to be present in plasma/serum of healthy individuals in levels ranging from 22 to 119 ng/ml.