| Cat. No. | Size |
Price |
|
|---|---|---|---|
| New RA19026R | 96 wells (1 kit) |
Competitive ELISA
Plasma-EDTA
50 µl/well
On ice. Upon receipt, store the product at the temperature recommended below.
Store the kit at -20°C. Under these conditions, the kit is stable until expiration date (see label on the box).
0.2 - 25 ng/mL
Autoimmunity, Energy metabolism and body weight regulation, Immune Response, Infection and Inflammation
LEAP-2 is a member of the liver-expressed antimicrobial peptide (LEAP) family. It is a 40-amino acid peptide cleaved from a 77-amino acid precursor by a furin-like endoprotease. The LEAP-2 peptide is rich in cysteine and contains two disulfide bonds formed by cysteine residues at the 1-3 and 2-4 positions. Highly conserved among mammals, LEAP-2 is expressed by hepatocytes in the liver, as well as in the small intestine and central nervous system.
Originally identified as an antimicrobial peptide, LEAP-2 plays a role in the innate immune system by fighting bacterial infections. It has also been implicated in inflammatory processes, particularly in patients with rheumatoid arthritis, an autoimmune disease. Recent studies have shown that LEAP-2 has an anorexigenic effect and acts as a ghrelin antagonist. In addition, plasma levels of LEAP-2 are elevated in obese patients.