| Cat. No. | Size |
Price |
|
|---|---|---|---|
| RAG026R | 96 wells (1 kit) | $664 |
Sandwich ELISA, Biotin-labelled antibody
Serum, Plasma, Cell culture supernatant
5µl/well
Store the complete kit at 2–8°C. Under these conditions, the kit is stable until the expiration date (see label on the box).
7.8 - 500 pg/ml
4 pg/ml
n = 6
CV = 3.6%
n = 5
CV = 4.2%
82 - 103%
82 - 112%
It is intended for research use only
The total assay time is less than 4 hours
The kit measures IL-36alpha in serum, plasma and cell cuture supernatant
Assay format is 96 wells
Components of the kit are provided ready to use, concentrated or dried
Immune Response, Infection and Inflammation
IL-36α and IL-36β augmented IL-17A-mediated induction of antibacterial peptides in psoriasis. A significant increase in circulating and tissue levels of IL-36α occurs in Sjögren’s syndrome patients. An increased expression of IL-36 α and IL-36 γ, but not IL-36 β has been observed in colonic inflammatory lesions from patients with inflammatory bowel disease, more prominently in ulcerative colitis. An association between IL-36 and Th17 responses was also confirmed in Crohn’s disease, although the expression of IL-36 in this population was significantly lower than in psoriasis. All members of the IL-36 subfamily are expressed during estrous cycle and pregnancy. IL-36α has also been involved in the prognosis of hepatocellular carcinoma, where its expression correlates negatively with tumor size, degree of differentiation, and level of vascular invasion. Correspondingly, high levels of IL-36α are positively correlated to the overall survival of patients.