Type
Sandwich ELISA
Applications
Plasma-EDTA, Urine
Sample Requirements
50 µl/well
Shipping
Shipped on blue ice packs. Upon receipt, store the product at the temperature recommended below.
Storage/Expiration
Store the complete kit at 2–8°C. Under these conditions, all components are stable until the expiration date (see label on the box).
Calibration Range
50 - 2000 pg/ml
Limit of Detection
25 pg/ml
Intra-assay (Within-Run)
n = 8
CV = 4.8%
Inter-assay (Run-to-Run)
n = 8
CV = 9.2%
Spiking Recovery
88.0%
Dilution Linearity
107.3%
Features
It is intended for research use only
The total assay time is less than 20 hours
The kit measures FGF-23
Assay format is 96 wells
Quality Controls are human serum based
Standard is a recombinant protein
Components of the kit are provided ready to use, concentrated or dried
Research topic
Bone and cartilage metabolism, Renal disease
Summary
Fibroblast growth factor-23 (FGF-23) is a phosphaturic hormone involved in mineral bone metabolism that helps control phosphate homeostasis and reduces 1,25- dihydroxyvitamin D synthesis. Recent data have highlighted the relevant direct FGF-23 effects on the myocardium, and high plasma levels of FGF-23 have been associated with adverse cardiovascular outcomes in humans, such as heart failure and arrhythmias. Therefore, FGF-23 has emerged as a novel biomarker of cardiovascular risk. experimental data suggest FGF-23 as a direct mediator of cardiac hypertrophy development, cardiac fibrosis and cardiac dysfunction via specific myocardial FGF receptor (FGFR) activation.
Instructions for Use (RUO)
Instructions for Use (RUO)
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