| Cat. No. | Size |
Price |
|
|---|---|---|---|
| RHK386-01R | 96 wells (1 kit) | $871,09 |
Sandwich ELISA, Biotin-labelled antibody
Serum, Plasma
10 µl/well
Store the complete kit at 2–8°C. Under these conditions, the kit is stable until the expiration date (see label on the box).
1.6-100 ng/ml
1.6 ng/ml
3.5 %
7.6 %
The total assay time is 3.5 hours
The kit measures Arginase Liver Type in human Serum and Plasma
Assay format is 96 wells
Components of the kit are provided ready to use or concentrated
Asthma and allergic rhinitis, Blood pressure regulation and NO metabolism, Immunology, Oncology, Pulmonary diseases
Arginase-I (liver-type Arginase, L-arginine ureahydrolase, or L-arginine amidinohydrolase) is an hydrolytic enzyme that converts arginine to ornithine and urea. Ornithine is the precursor for preline, an essential amino acid for collagen synthesis and for poly-amines, key components in cell growth and differentiation. Arginase exists as two forms designated Arginase-I and Arginase-II which are encoded by different genes. Although Arginase-I and Arginase-II have similar enzyme activities, they differ in immunological reactivity. Human Arginase-I (liver-type Arginase) is a 35 kDa protein circulating in blood probably as a homotrimer. Liver-type Arginase is most abundant expressed in mammalian liver, but is also found in non-hepatic tissues, for instance red blood cells, lactating mammalian glands, and the kidney. In addition to its involvement in ammonia detoxification via the urea cycle, Arginase plays a role in other processes, for instance macrophage-mediated cytotoxicity due to Arginase release and inhibition of lymphocyte proliferation in vitro. It shows high activity in growing tissues, wound healing, proliferating lymphocytes and tumors. Furthermore, Arginase acts as a modulator of the immune response. Besides this Arginase plays a role in allergen challenged lungs, in autoimmune inflammation in the central nervous system and in acute liver injury.