| Cat. No. | Size |
Price |
|
|---|---|---|---|
| Discount IC6500 | 96 wells (1 kit) | $675 |
Sandwich ELISA, HRP-labelled antibody
Stool
Store the complete kit at 2–8°C. Under these conditions, the kit is stable until the expiration date (see label on the box).
0.05 ng/ml
n = 10; CV = 6.8 %
n = 10; CV = 8.7 %
100.52%
103.31%
Diabetology - Autoimmunity
After activation eosinophil granulocytes are segregating the cationic glycoprotein EDN (eosinophil derived neurotoxin). This 18-21 kDa single stranded glycosylated protein is also known as EPX (eosinophil protein X). Together with ECP (eosinophil cationic protein) EDN belongs to the ribonuclease superfamily. However EDN has a 100-fold increased ribonuclease activity. It is neurotoxic but not cytotoxic. The activation of eosinophil granulocytes is important during inflammatory processes in allergic reactions. Thus EDN is a marker for eosinophil activation and degranulation. The measurement of EDN in stool allows the detection of clinical or subclinical chronic inflammation in the gut. In patients with colitis ulcerosa and/or morbus crohn, the measurement of EDN gives information on the activity of the disease and the prediction of a relapse.
Applications:
The ImmuChrom complete EDN kit allows an easy, rapid and precise quantitative determination of the eosinophil derived neurotoxin in biological samples. The kit includes all reagents ready to use for preparation of the samples.