Type
Competitive ELISA, Immobilized antigen
Applications
Serum
Sample Requirements
50 μl/well
Shipping
At ambient temperature. Upon receipt, store the product at the temperature recommended below.
Storage/Expiration
Store the complete kit at 2–8°C. Under these conditions, the kit is stable until the expiration date (see label on the box).
Calibration Curve
Calibration Range
0.15–20 ng/ml
Limit of Detection
0.11 ng/ml
Intra-assay (Within-Run)
CV = 5.3%
Inter-assay (Run-to-Run)
CV = 6.8%
Spiking Recovery
98,00%
Dilution Linearity
97,00%
Research topic
Steroid hormones
Summary
The steroid 17α−OH Progesterone is produced by the adrenal cortex and gonads. The 17α−OH Progesterone has little progestational activity, but it is of intense clinical interest because it is the immediate precursor to 11-desoxycortisol (Cpd-S). Cpd-S is produced by 21-hydroxylation of 17 OHP, measurement of 17aOHP is a useful indirect indicator of 21-hydroxlase activity. In congenital 21– hydroxylase deficiency, the most common variety of congenital adrenal hyperplasia (CAH), 17αOHP is secreted in abundant excess. Measurment of 17αOHP is therefore valuable in the initial diagnosis of CAH.
Instructions for Use (RUO)
Instructions for Use (RUO)
Safety Information (RUO)
MSDS (RUO)
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