Research topic
Cell apoptosis, Cell.cycle and Cell migration, Extracellular matrix, Growth hormone and factor-related products
Summary
Stable Fibroblast Growth Factor 2:
- FGF2, also known as basic FGF, bFGF
- Hyperstable protein
- More than 20-times the standard half-life in human cell culture incubated at 37 °C
- Engineered with fully retained biological function
- No harmful stabilizing additives
FGF2-STAB® is a stabilized growth factor that offers a novel way to grow FGF2-dependent cell cultures more efficiently, with fewer media changes. FGF2-STAB® retains full biological activity even after twenty days at 37 °C. The stable level of FGF2 in culture allows for a more homogenous, undifferentiated stem cell culture, while saving researchers valuable time and money because repeated supplementation of FGF2 and a daily medium change is not required.
FGF2 is a non-glycosylated heparin binding growth factor that is expressed in the brain, pituitary gland, kidney, retina, bone, testis, adrenal gland, liver, monocytes, epithelial cells and endothelia! cells. FGF2 functions as a pleiotropic regulator of proliferation, differentiation, migration, and survival in a variety of cell types and is an essential component of media for the cultivation of human pluripotent stem cells because it helps maintain the cells in the pluripotent state. This property makes cells valuable for studying embryogenesis, for drug discovery, and for cell-based therapies.
Potential industrial applications
FGF2 is a pleiotropic regulator of proliferation, differentiation, migration, and survival in a variety of cell types and is an essential component of media for the cultivation of pluripotent stem cells because it helps maintain the cells in the pluripotent state. Wild-type FGF2 is highly labile at 37 °C (its half-life is as low as 9 hours), therefore, daily media changes with fresh FGF2 are needed and cells are exposed to fluctuation of FGF2 concentration. FGF2-STAB® stable biological activity means fewer media changes and no fluctuation in concentration.
Research shows that FGF2 plays an important role in wound healing, diabetic foot ulcer treatment, periodontal regeneration, bone regrowth, cancer treatment, cardioprotection, neuroprotection, and treatment of mood disorders. A key driver in these fields is the aging of the global population, since age-related diseases increase a risk of damage to tissues and slow the healing process. A prolonged and sustained delivery of FGF2-STAB® provides greater therapeutic effect and faster healing.
FGF2 has been shown to increase skin elasticity, decrease the depth of wrinkles, increase the hydration of skin, decrease the depth of pigmentation and promote hair growth by inducing the anagen phase of hair follicles. Potential applications to skin care include rejuvenation of the epidermal cells and the underlying fibroblast cells, which produce collagen, elastin and hyaluronic acid. Since it is extremely difficult to keep labile FGF2 active in cosmetic products, stable FGF2-STAB® could truly make a difference.
Please request additional information before use in applications that require regulatory approval.
International patent pending.
